Isolated pulmonary mucormycosis in an immunocompetent patient: a case report and systematic review of the literature

BMC Pulm Med. 2021 Apr 27;21(1):138. doi: 10.1186/s12890-021-01504-8.

Abstract

Background: Pulmonary mucormycosis caused by Mucorales is a highly lethal invasive fungal infection usually found in immunocompromised patients. Isolated pulmonary mucormycosis in immunocompetent patients is very rare. Here, we present a case of a 32-year-old male who developed pulmonary mucormycosis without any known immunodeficiency.

Case presentation: The patient presented to our hospital because of cough and chest pain along with blood in the sputum. He was first treated for community-acquired pneumonia until bronchoalveolar lavage fluid culture confirmed the growth of Absidia. His symptoms were relieved with the use of amphotericin B, and he eventually recovered. We also provide a systematic review of relevant literature to summarize the characteristics of pulmonary mucormycosis in immunocompetent patients.

Conclusions: Pulmonary mucormycosis has variable clinical presentations and is difficult to identify. Due to its high fatality rate, clinicians should make judgements regarding suspected cases correctly and in a timely manner to avoid misdiagnosis and delayed treatment.

Keywords: Case report; Immunocompetent host; Pulmonary mucormycosis; Systematic review.

Publication types

  • Case Reports
  • Systematic Review

MeSH terms

  • Adult
  • Humans
  • Immunocompetence
  • Lung Diseases, Fungal / diagnostic imaging*
  • Male
  • Mucormycosis / diagnostic imaging*