Discovery of α-helix-mimicking sulfono-γ-AApeptides as p53-MDM2 inhibitors

Future Med Chem. 2021 Jun;13(12):1021-1023. doi: 10.4155/fmc-2021-0044. Epub 2021 Apr 28.

Authors

Yan Shi¹, Peng Sang¹, Jianfeng Cai¹

Affiliation

¹ Department of Chemistry, University of South Florida, 4202 E, Fowler Avenue, Tampa, FL 33620, USA.

PMID: 33906432
DOI: 10.4155/fmc-2021-0044

No abstract available

Keywords: foldamers; helical; inhibitors; peptidomimetics; protein−protein interactions; sulfono-γ-AApeptide.

Publication types

Editorial
Review

MeSH terms

Drug Discovery*
Humans
Peptides / chemistry
Peptides / pharmacology*
Peptidomimetics / chemistry
Peptidomimetics / pharmacology*
Protein Conformation, alpha-Helical
Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors*
Proto-Oncogene Proteins c-mdm2 / metabolism
Tumor Suppressor Protein p53 / antagonists & inhibitors*
Tumor Suppressor Protein p53 / metabolism

Substances

Peptides
Peptidomimetics
Tumor Suppressor Protein p53
MDM2 protein, human
Proto-Oncogene Proteins c-mdm2