Four new phenanthrene derivatives from Bulbophyllum retusiusculum

Yun-Shan Fang; Ming-Hui Yang; Jia-Peng Wang; Huan Fu; Le Cai; Zhong-Tao Ding

doi:10.1016/j.fitote.2021.104910

Four new phenanthrene derivatives from Bulbophyllum retusiusculum

Fitoterapia. 2021 Jul:152:104910. doi: 10.1016/j.fitote.2021.104910. Epub 2021 Apr 24.

Authors

Yun-Shan Fang¹, Ming-Hui Yang², Jia-Peng Wang³, Huan Fu², Le Cai⁴, Zhong-Tao Ding⁵

Affiliations

¹ School of Chemistry and Chemical Engineering, Kunming University, Kunming 650214, China.
² College of pharmacy, Dali University, Dali 671000, China.
³ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
⁴ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: caile@ynu.edu.cn.
⁵ Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; College of pharmacy, Dali University, Dali 671000, China. Electronic address: ztding@ynu.edu.cn.

PMID: 33905817
DOI: 10.1016/j.fitote.2021.104910

Abstract

Three new dihydrophenanthrenes, retusiusine D (1), retusiusine E (2), retusiusine F (3), and a new phenanthrene retusiusine G (4), together with two known dihydrophenanthrenes 4,7-dihydroxy-2,3-methylenedioxy-9,10-dihydrophenanthrene (5) and epemeranthol-A (6) were isolated from the tubers of Bulbophyllum retusiusculum. Their structures were established on the basis of extensive spectroscopic analyses. Compounds 1 and 2 exhibited potent cytotoxic activities against SMMC-7721 and weak cytotoxic activities against HL-60. Compound 4 showed moderate cytotoxic activity against SMMC-7721 and MCF-7.

Keywords: Bulbophyllum retusiusculum; Cytotoxic activity; Dihydrophenanthrene; Phenanthrene; Retusiusine.

MeSH terms

Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Humans
Molecular Structure
Orchidaceae / chemistry*
Phenanthrenes / isolation & purification
Phenanthrenes / pharmacology*
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plant Tubers / chemistry

Substances

Antineoplastic Agents, Phytogenic
Phenanthrenes
Phytochemicals