Assessment of toxicological potential of sodium carboxymethyl beta-glucan, a novel beta-glucan

Food Chem Toxicol. 2021 Jun:152:112226. doi: 10.1016/j.fct.2021.112226. Epub 2021 Apr 24.

Abstract

In this experimental work, sodium carboxymethyl beta-glucan (CMBG), a chemically altered beta-glucan, is evaluated for mutagenicity and sub-acute oral toxicity. Specifically, the tested material was CM-Glucan Nu, a food grade powder ≥90% CMBG derived from Saccharomyces cerevisiae. A bacterial reverse mutation test was performed and resulted in no mutagenicity. A 28-day, repeated-dose, oral (gavage) toxicity test on rats was performed at dose levels of 0, 500, 1000, and 2000 mg/kg bw/day. No mortality, target organs or other treatment related effects were observed. The no observed adverse effect level (NOAEL) was 2000 mg/kg bw/day, the highest dose tested, for both male and female Han:WIST rats.

Keywords: Mutagenicity; NOAEL; Safety; Sodium carboxymethyl beta-glucan; Toxicity.

MeSH terms

  • Administration, Oral
  • Animals
  • Escherichia coli / drug effects
  • Female
  • Male
  • Mutagenicity Tests
  • No-Observed-Adverse-Effect Level
  • Rats
  • Rats, Wistar
  • Saccharomyces cerevisiae / chemistry
  • Salmonella typhimurium / drug effects
  • Toxicity Tests, Subacute
  • beta-Glucans / administration & dosage
  • beta-Glucans / toxicity*

Substances

  • beta-Glucans
  • carboxymethyl-beta-1,3-glucan