Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics

Cole J Batty; Eric M Bachelder; Kristy M Ainslie

doi:10.1016/j.molmed.2021.04.002

Historical Perspective of Clinical Nano and Microparticle Formulations for Delivery of Therapeutics

Trends Mol Med. 2021 Jun;27(6):516-519. doi: 10.1016/j.molmed.2021.04.002. Epub 2021 Apr 23.

Authors

Cole J Batty¹, Eric M Bachelder¹, Kristy M Ainslie²

Affiliations

¹ Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina, Chapel Hill, NC 27599, USA.
² Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North State University, Chapel Hill, NC 27599, USA. Electronic address: ainsliek@email.unc.edu.

Abstract

Nano and micro-technologies are used for therapeutic delivery of biologics and small molecules in formulations ranging in size from one nanometer to 100 microns or more. Here we review the unique physiochemical properties of these technologies and how they lead to more beneficial drug pharmacokinetics and toxicity over conventional formulations.

Keywords: emulsions; lipid nanoparticles; liposomes; polymeric nanoparticles.

Publication types

Historical Article
Research Support, N.I.H., Extramural
Review

MeSH terms

Drug Carriers / chemistry*
Drug Delivery Systems*
History, 20th Century
History, 21st Century
Humans
Nanoparticles / administration & dosage
Nanoparticles / chemistry*
Nanotechnology / history*
Particle Size
Pharmaceutical Preparations / administration & dosage*
Pharmaceutical Preparations / chemistry
Polymers / chemistry*

Substances

Drug Carriers
Pharmaceutical Preparations
Polymers

Grants and funding

R01 AI147497/AI/NIAID NIH HHS/United States