Gut-Based Strategies to Reduce Postprandial Glycaemia in Type 2 Diabetes

Md Kamruzzaman; Michael Horowitz; Karen L Jones; Chinmay S Marathe

doi:10.3389/fendo.2021.661877

Gut-Based Strategies to Reduce Postprandial Glycaemia in Type 2 Diabetes

Front Endocrinol (Lausanne). 2021 Apr 9:12:661877. doi: 10.3389/fendo.2021.661877. eCollection 2021.

Authors

Md Kamruzzaman¹, Michael Horowitz^{2

3}, Karen L Jones^{2

3}, Chinmay S Marathe^{2

3}

Affiliations

¹ Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
² Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
³ Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia.

Abstract

Postprandial glycemic control is an important target for optimal type 2 diabetes management, but is often difficult to achieve. The gastrointestinal tract plays a major role in modulating postprandial glycaemia in both health and diabetes. The various strategies that have been proposed to modulate gastrointestinal function, particularly by slowing gastric emptying and/or stimulating incretin hormone GLP-1, are summarized in this review.

Keywords: GLP-1 receptor agonist; gastric emptying; incretin hormones; postprandial glucose (PPG); type 2 diabetes.

Publication types

Review

MeSH terms

Blood Glucose*
Diabetes Mellitus, Type 2* / blood
Diabetes Mellitus, Type 2* / metabolism
Diabetes Mellitus, Type 2* / therapy
Gastric Emptying*
Glucagon-Like Peptide 1 / metabolism*
Humans
Incretins / metabolism*
Postprandial Period*

Substances

Blood Glucose
Incretins
Glucagon-Like Peptide 1