Lipid Metabolism Profiles in Rheumatic Diseases

Weilin Chen; Qi Wang; Bin Zhou; Lihua Zhang; Honglin Zhu

doi:10.3389/fphar.2021.643520

Lipid Metabolism Profiles in Rheumatic Diseases

Front Pharmacol. 2021 Apr 9:12:643520. doi: 10.3389/fphar.2021.643520. eCollection 2021.

Authors

Weilin Chen^{1

2

3}, Qi Wang⁴, Bin Zhou⁵, Lihua Zhang⁶, Honglin Zhu^{1

2

3}

Affiliations

¹ Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China.
² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.
³ Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Changsha, China.
⁴ Department of Radiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.
⁵ Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
⁶ Department of Rheumatology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.

Abstract

Rheumatic diseases are a group of chronic autoimmune disorders that involve multiple organs or systems and have high mortality. The mechanisms of these diseases are still ill-defined, and targeted therapeutic strategies are still challenging for physicians. Recent research indicates that cell metabolism plays important roles in the pathogenesis of rheumatic diseases. In this review, we mainly focus on lipid metabolism profiles (dyslipidaemia, fatty acid metabolism) and mechanisms in rheumatic diseases and discuss potential clinical applications based on lipid metabolism profiles.

Keywords: dyslipidemia; fatty acid metabolism; lipid metablism; rheumatic diseases; statin.

Publication types

Review