Asparagine, a Key Metabolite in Cellular Response to Mitochondrial Dysfunction

Yuyang Liu; Kıvanç Birsoy

doi:10.1016/j.trecan.2021.04.001

Asparagine, a Key Metabolite in Cellular Response to Mitochondrial Dysfunction

Trends Cancer. 2021 Jun;7(6):479-481. doi: 10.1016/j.trecan.2021.04.001. Epub 2021 Apr 23.

Authors

Yuyang Liu¹, Kıvanç Birsoy²

Affiliations

¹ Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
² Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: kbirsoy@rockefeller.edu.

PMID: 33896762
DOI: 10.1016/j.trecan.2021.04.001

Abstract

The mitochondrial electron transport chain (ETC) has been an attractive target for cancer therapy due to its essentiality for tumor growth. Krall et al. found that under ETC dysfunction, a decrease in asparagine limits cancer cell proliferation and activates the integrated stress response, creating a therapeutically exploitable metabolic vulnerability.

Publication types

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MeSH terms

Asparagine*
Cell Line, Tumor
Cell Proliferation
Mitochondria*

Substances

Asparagine