A critical review on the use of potentiometric based biosensors for biomarkers detection

Hassan Karimi-Maleh; Yasin Orooji; Fatemeh Karimi; Marzieh Alizadeh; Mehdi Baghayeri; Jalal Rouhi; Somayeh Tajik; Hadi Beitollahi; Shilpi Agarwal; Vinod K Gupta; Saravanan Rajendran; Ali Ayati; Li Fu; Afsaneh L Sanati; Bahareh Tanhaei; Fatih Sen; Mehdi Shabani-Nooshabadi; Padideh Naderi Asrami; Amani Al-Othman

doi:10.1016/j.bios.2021.113252

A critical review on the use of potentiometric based biosensors for biomarkers detection

Biosens Bioelectron. 2021 Jul 15:184:113252. doi: 10.1016/j.bios.2021.113252. Epub 2021 Apr 17.

Authors

Hassan Karimi-Maleh¹, Yasin Orooji², Fatemeh Karimi³, Marzieh Alizadeh⁴, Mehdi Baghayeri⁵, Jalal Rouhi⁶, Somayeh Tajik⁷, Hadi Beitollahi⁸, Shilpi Agarwal⁹, Vinod K Gupta⁹, Saravanan Rajendran¹⁰, Ali Ayati¹¹, Li Fu¹², Afsaneh L Sanati¹³, Bahareh Tanhaei¹¹, Fatih Sen¹⁴, Mehdi Shabani-Nooshabadi¹⁵, Padideh Naderi Asrami¹⁶, Amani Al-Othman¹⁷

Affiliations

¹ School of Resources and Environment, University of Electronic Science and Technology of China, P.O. Box 611731, Xiyuan Ave, Chengdu, PR China; Department of Chemical Engineering and Energy, Quchan University of Technology, Quchan, 9477177870, Iran; Department of Chemical Sciences, University of Johannesburg, Doornfontein Campus, 2028 Johannesburg, P.O. Box 17011, South Africa. Electronic address: hassan@uestc.edu.cn.
² College of Materials Science and Engineering, Nanjing Forestry University, 159 Longpan Road, Nanjing 210037, China; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China. Electronic address: yasin@njfu.edu.cn.
³ Department of Chemical Engineering and Energy, Quchan University of Technology, Quchan, 9477177870, Iran. Electronic address: fkm024@gmail.com.
⁴ Laboratory of Basic Sciences, Mohammad Rasul Allah Research Tower, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran.
⁵ Department of Chemistry, Faculty of Science, Hakim Sabzevari University, PO. Box 397, Sabzevar, Iran.
⁶ Faculty of Physics, University of Tabriz, Tabriz, 51566, Iran.
⁷ Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, 7616913555, Iran.
⁸ Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, 7631133131, Iran.
⁹ Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
¹⁰ Faculty of Engineering, Department of Mechanical Engineering, University of Tarapaca, Avda. General Velasquez, 1775 Arica, Chile.
¹¹ Department of Chemical Engineering and Energy, Quchan University of Technology, Quchan, 9477177870, Iran.
¹² College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, 310018, PR China.
¹³ Institute of Systems and Robotics, Department of Electrical and Computer Engineering, University of Coimbra, Polo II, 3030-290, Coimbra, Portugal. Electronic address: a.sanati86@gmail.com.
¹⁴ Sen Research Group, Department of Biochemistry, Faculty of Arts and Science, Dumlupınar University, Evliya Çelebi Campus, 43100, Kütahya, Turkey.
¹⁵ Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran.
¹⁶ Massoud Clinical Laboratory, Tehran, Iran. Electronic address: p.naderi@gmail.com.
¹⁷ Department of Chemical Engineering, American University of Sharjah, Sharjah, PO. Box 26666, United Arab Emirates.

PMID: 33895688
DOI: 10.1016/j.bios.2021.113252

Abstract

Potentiometric-based biosensors have the potential to advance the detection of several biological compounds and help in early diagnosis of various diseases. They belong to the portable analytical class of biosensors for monitoring biomarkers in the human body. They contain ion-sensitive membranes sensors can be used to determine potassium, sodium, and chloride ions activity while being used as a biomarker to gauge human health. The potentiometric based ion-sensitive membrane systems can be coupled with various techniques to create a sensitive tool for the fast and early detection of cancer biomarkers and other critical biological compounds. This paper discusses the application of potentiometric-based biosensors and classifies them into four major categories: photoelectrochemical potentiometric biomarkers, potentiometric biosensors amplified with molecular imprinted polymer systems, wearable potentiometric biomarkers and light-addressable potentiometric biosensors. This review demonstrated the development of several innovative biosensor-based techniques that could potentially provide reliable tools to test biomarkers. Some challenges however remain, but these can be removed by coupling techniques to maximize the testing sensitivity.

Keywords: Biomarkers; Light-addressable systems; Molecularly imprinted polymers; Photoelectrochemical; Potentiometric systems; Wearable systems.

Publication types

Review

MeSH terms

Biomarkers
Biosensing Techniques*
Humans
Polymers
Potentiometry

Substances

Biomarkers
Polymers