Erythropoesis-Stimulating Properties of Anthocyanin-Containing Complexes in Cytostatic Anemic Syndrome

Bull Exp Biol Med. 2021 Apr;170(6):769-773. doi: 10.1007/s10517-021-05151-1. Epub 2021 Apr 24.

Abstract

We studied the effect of an anthocyanin-containing complex from Sorbus aucuparia L. on the main indicators of erythropoiesis in the blood and bone marrow of mice against the background of doxorubicin treatment. It was shown that administration of an anthocyanincontaining complex from S. aucuparia L. prevented the development of anemic syndrome by stimulating regeneration of the erythroid lineage of hematopoiesis after its devastation by single administration of the cytostatic.

Keywords: anemic syndrome; anthocyanin-containing complex; doxorubicin.

MeSH terms

  • Anemia / genetics
  • Anemia / metabolism
  • Animals
  • Anthocyanins / genetics
  • Anthocyanins / metabolism*
  • Doxorubicin / therapeutic use
  • Erythropoiesis / genetics
  • Erythropoiesis / physiology*
  • Hematopoiesis / genetics
  • Hematopoiesis / physiology
  • Male
  • Mice
  • Mice, Inbred C57BL

Substances

  • Anthocyanins
  • Doxorubicin