Inflammatory microenvironment-targeted nanotherapies

Guangshuai Zhang; Lixue Ma; Lijun Bai; Mo Li; Tiange Guo; Baocheng Tian; Zhonggui He; Qiang Fu

doi:10.1016/j.jconrel.2021.04.018

Inflammatory microenvironment-targeted nanotherapies

J Control Release. 2021 Jun 10:334:114-126. doi: 10.1016/j.jconrel.2021.04.018. Epub 2021 Apr 20.

Authors

Guangshuai Zhang¹, Lixue Ma², Lijun Bai², Mo Li³, Tiange Guo⁴, Baocheng Tian⁵, Zhonggui He², Qiang Fu⁶

Affiliations

¹ Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Electronic address: zhangguangshuai5@163.com.
² Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
³ Liaoning Institute for Drug Control, No. 7 Chongshan West Road, Shenyang 110016, China.
⁴ Laboratory Animal Department, General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenyang 110016, China.
⁵ School of Pharmacy, Binzhou Medical University, No. 346, Guanhai Road, Yantai 264003, China.
⁶ Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Electronic address: fuqiang@syphu.edu.cn.

PMID: 33887284
DOI: 10.1016/j.jconrel.2021.04.018

Abstract

Inflammatory microenvironments (IMEs) are common pathological characteristics and drive the development of multiple chronic diseases. Thus, IME-targeted therapies exhibit potential for the treatment of inflammatory diseases. Nanoplatforms have significant advantages in improving the efficiency of anti-inflammatory treatments. Owing to their improved therapeutic effects and reduced side effects, IME-targeted nanotherapies have recently drawn interest from the research community. This review introduces IMEs and discusses the application of IME-targeted nanotherapies for inflammatory diseases. The development of rational targeting strategies tailored to IMEs in damaged tissues can help promote therapies for chronic diseases.

Keywords: Chronic diseases; Inflammatory microenvironments; Nanotherapies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Inflammatory Agents*

Substances

Anti-Inflammatory Agents