Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition

Sofie V Nielsen; Rasmus Hartmann-Petersen; Amelie Stein; Kresten Lindorff-Larsen

doi:10.1371/journal.pgen.1009496

Multiplexed assays reveal effects of missense variants in MSH2 and cancer predisposition

PLoS Genet. 2021 Apr 22;17(4):e1009496. doi: 10.1371/journal.pgen.1009496. eCollection 2021 Apr.

Authors

Sofie V Nielsen¹, Rasmus Hartmann-Petersen¹, Amelie Stein¹, Kresten Lindorff-Larsen¹

Affiliation

¹ Department of Biology, The Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Mismatch Repair / genetics
Genetic Predisposition to Disease*
Humans
MutS Homolog 2 Protein / genetics*
Mutation, Missense / genetics
Neoplasms / genetics*
Neoplasms / pathology

Substances

MSH2 protein, human
MutS Homolog 2 Protein

Grants and funding

Our research is supported by the PRISM (Protein Interactions and Stability in Medicine and Genomics) centre funded by the Novo Nordisk Foundation (to RHP, AS and KLL; NNF18OC0033950) and the Lundbeck Foundation (to AS; R272-2017-4528). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.