ADAM17 Boosts Cholesterol Efflux and Downstream Effects of High-Density Lipoprotein on Inflammatory Pathways in Macrophages

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1854-1873. doi: 10.1161/ATVBAHA.121.315145. Epub 2021 Apr 22.

Abstract

[Figure: see text].

Keywords: ADAM17 protein; HDL; cholesterol; inflammation; lipoproteins; macrophages.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADAM17 Protein / genetics
  • ADAM17 Protein / metabolism*
  • ATP Binding Cassette Transporter 1 / metabolism
  • Animals
  • Apolipoprotein A-I / genetics
  • Apolipoprotein A-I / metabolism
  • Cells, Cultured
  • Chemokine CCL2 / genetics
  • Chemokine CCL2 / metabolism
  • Chemokine CXCL1 / genetics
  • Chemokine CXCL1 / metabolism
  • Cholesterol / metabolism*
  • Cholesterol, HDL / metabolism
  • Female
  • Inflammation / enzymology*
  • Inflammation / genetics
  • Inflammation Mediators / metabolism*
  • Interleukin-1beta / genetics
  • Interleukin-1beta / metabolism
  • Lipoproteins, HDL / metabolism*
  • Macrophages, Peritoneal / enzymology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism
  • Signal Transduction
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • ABCA1 protein, mouse
  • APOA1 protein, human
  • ATP Binding Cassette Transporter 1
  • Apolipoprotein A-I
  • Ccl2 protein, mouse
  • Chemokine CCL2
  • Chemokine CXCL1
  • Cholesterol, HDL
  • Cxcl1 protein, mouse
  • IL1B protein, mouse
  • Inflammation Mediators
  • Interleukin-1beta
  • Lipoproteins, HDL
  • Receptors, LDL
  • Tnf protein, mouse
  • Tumor Necrosis Factor-alpha
  • Cholesterol
  • ADAM17 Protein
  • Adam17 protein, mouse