Role of Natural Plant Products Against Alzheimer's Disease

CNS Neurol Disord Drug Targets. 2021;20(10):904-941. doi: 10.2174/1871527320666210420135437.

Abstract

Alzheimer's Disease (AD) is one of the major neurodegenerative disorders. Deposition of amyloid fibrils and tau protein is associated with various pathological symptoms. Currently, limited medication is available for AD treatment. Most of the drugs are basically cholinesterase inhibitors and associated with various side effects. Natural plant products have shown potential as a therapeutic agent for the treatment of AD symptoms. A variety of secondary metabolites such as flavonoids, tannins, terpenoids, alkaloids, and phenols are used to reduce the progression of the disease. Plant products have fewer or no side effects and are easily available. The present review gives a detailed account of the potential of natural plant products against AD symptoms.

Keywords: AD symptoms; Alzheimer's disease; natural plant products; pathogenesis; secondary metabolites.; treatment.

Publication types

  • Review

MeSH terms

  • Alkaloids / therapeutic use
  • Alzheimer Disease / drug therapy*
  • Animals
  • Biological Products / therapeutic use*
  • Flavonoids / therapeutic use
  • Humans
  • Neuroprotective Agents / therapeutic use*
  • tau Proteins

Substances

  • Alkaloids
  • Biological Products
  • Flavonoids
  • MAPT protein, human
  • Neuroprotective Agents
  • tau Proteins