Perivascular Macrophages Regulate Blood Flow Following Tissue Damage

Circ Res. 2021 May 28;128(11):1694-1707. doi: 10.1161/CIRCRESAHA.120.318380. Epub 2021 Apr 21.

Abstract

[Figure: see text].

Keywords: ischemia; morbidity; perfusion; peripheral artery disease; plasmids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Movement
  • Cell Proliferation
  • Chemokine CCL2 / metabolism
  • Chemokine CXCL12 / metabolism*
  • Humans
  • Ischemia / physiopathology
  • Ischemia / therapy*
  • Macrophages / cytology
  • Macrophages / metabolism
  • Macrophages / physiology*
  • Mice
  • Muscle, Skeletal / blood supply*
  • Nitric Oxide / metabolism
  • Nitric Oxide Synthase Type II / deficiency
  • Nitric Oxide Synthase Type II / metabolism*
  • Nitric Oxide Synthase Type III / metabolism
  • Plasmids / metabolism
  • Receptors, CCR2 / metabolism
  • Receptors, CXCR4 / metabolism
  • Regional Blood Flow / physiology*

Substances

  • Chemokine CCL2
  • Chemokine CXCL12
  • Receptors, CCR2
  • Receptors, CXCR4
  • Nitric Oxide
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase Type III