Is treated hypertension associated with a lower 1-year mortality among older multimorbid residents of long-term care facilities?

Pol Arch Intern Med. 2021 May 25;131(5):439-446. doi: 10.20452/pamw.15944. Epub 2021 Apr 20.

Abstract

Introduction: Long-term care facility (LTCF) residents are typically excluded from clinical trials due to multimorbidity, dementia, and frailty, so there are no clear evidence-based rules for treating arterial hypertension in this population. Moreover, the role of hypertension as mortality risk factor in LTCFs has not yet been clearly established.

Objectives: The study aimed to investigate whether treated hypertension is associated with lower mortality among older LTCF residents with multimorbidity.

Patients and methods: The study was performed in a group of 168 residents aged ≥ 65 years in three LTCFs. Initial assessment included blood pressure (BP) measurements and selected geriatric scales: MNA-SF, AMTS and ADL. Hypertension, comorbidities, pharmacotherapy, antihypertensive drugs and mortality during one-year follow-up were extracted from the medical records. The data was compared in groups: Survivors and Deceased.

Results: Survivors and Deceased revealed similar age, DBP, number of diseases, medications, and antihypertensive drugs. However, Deceased had significantly lower SBP (P <0.05) and presented significantly worse functional, nutritional and cognitive status than Survivors (P <0.001). Hypertension (P <0.001) and antihypertensive therapy (P <0.05) were significantly more frequent among Survivors. Significantly more of the hypertensive-treated than other multimorbid residents survived the follow-up (P <0.001). Logistic regression analysis showed that treated hypertension had a protective effect on mortality [OR = 0.11 (95% CI, 0.03-0.39); P <0.001].

Conclusions: One-year survival of LTCF residents with treated hypertension was significantly higher than the others. Appropriate antihypertensive therapy may be a protective factor against death in frail nursing home residents, even in short period of time.

MeSH terms

  • Aged
  • Antihypertensive Agents / therapeutic use
  • Humans
  • Hypertension* / drug therapy
  • Hypertension* / epidemiology
  • Long-Term Care*
  • Multimorbidity
  • Risk Factors

Substances

  • Antihypertensive Agents