Electrochemical synthesis of sulfamides

Chem Commun (Camb). 2021 May 13;57(39):4775-4778. doi: 10.1039/d1cc01428e.

Abstract

Herein we demonstrate the first electrochemical synthesis protocol of symmetrical sulfamides directly from anilines and SO2 mediated by iodide. Sulfamides are an emerging functional group in drug design. Highlights are the direct use of SO2 from a stock solution and no necessity of any supporting electrolyte. Overall, the reaction has been demonstrated for 15 examples with yields up to 93%.