Aim: Patients with chronic kidney disease (CKD) are at increased cardiovascular risk. Methods: Patients with acute coronary syndrome were retrospectively allocated to three groups (stage 3A, stage 3B or stage 4) based on the Kidney Disease Improving Global Outcomes classification formulas: the CKD Epidemiology Collaboration (CKD-EPI; N = 401) and the modification of diet in renal disease (n = 355). The primary end point was all-cause mortality (median follow-up time, 32 months [15-70]). Results: Study results showed decreased median survival was associated with poor renal function for both the CKD-EPI (78 vs 61 vs 40 months, p = 0.014) and modification of diet in renal disease groups (68 vs 57 vs 32 months, p = 0.006). After adjustment, age (OR: 1.07; 95% CI: 1.01-1.14) and pulmonary artery systolic pressure (OR: 1.08; 95% CI: 1.03-1.14), but not estimated glomerular filtration rate, were associated with decreased survival. Conclusion: Study results suggest that poor outcomes after an acute coronary syndrome were associated with comorbidities rather than estimated glomerular filtration rate level.
Keywords: acute coronary syndrome; chronic kidney disease; estimated glomerular filtration rate; prognosis.
Lay abstract Patients with chronic kidney failure have an elevated risk of heart attack or death. We studied patients with kidney failure and concurrent heart attack for 32 months (median). Our results suggest that poorer renal function was associated with an increased risk of death. However, the most important factors associated with survival were patient age and pulmonary artery systolic pressure and not the particular kidney function. Therefore, in this group of patients, comorbidities appear to play a role as survival determinants.