A case series of platelet rich plasma in chronic venous ulcers

Stephany Cares Huber; Beatriz de Moraes Martinelli; Melissa Quintero; Lais Ívina Silva de Paula; Jose Luiz Cataldo; Silmara Aparecida de Lima Montalvão; Joyce M Annichino-Bizzacchi

doi:10.1016/j.reth.2021.03.005

A case series of platelet rich plasma in chronic venous ulcers

Regen Ther. 2021 Apr 5:18:51-58. doi: 10.1016/j.reth.2021.03.005. eCollection 2021 Dec.

Authors

Stephany Cares Huber¹, Beatriz de Moraes Martinelli¹, Melissa Quintero¹, Lais Ívina Silva de Paula¹, Jose Luiz Cataldo¹, Silmara Aparecida de Lima Montalvão¹, Joyce M Annichino-Bizzacchi¹

Affiliation

¹ Hematology and Hemotherapy Center, Hemocentro, University of Campinas (UNICAMP), Campinas, Brazil.

Abstract

Introduction: Venous ulcers are the most common type of leg wounds (80%) and the main cause is chronic venous insufficiency. Autologous platelet-rich plasma (PRP) is a potential wound healing treatment due to its great variety of growth factors. The aim of this study was to describe in a case series the results of poor-leukocyte PRP (P-PRP) or saline for the treatment of chronic non-healing ulcers of the lower extremity.

Methods: Eight patients were treated according to the topical therapy: saline solution or P-PRP gel. All patients used double compression stocks and were assisted by a vascular practitioner for up to 12 months or until wound healing. The treatment was performed weekly with cleaning of the affected area, macroscopic evaluation (area measurement and photos) and P-PRP or saline application, and closure with Tegaderm®. Trial Registration: Retrospectively approved by Brazilian Clinical Trials, register number RBR-7zhgb3 (http://www.ensaiosclinicos.gov.br/rg/RBR-7zhgb3/).

Results: All patients showed signs of wound healing with a reduction in wound size and ulcer numbers, but more evident with P-PRP application.

Conclusions: The results suggested that P-PRP presented a better result when compared to saline solution in the healing process of long clinical course chronic venous ulcers, when associated to compressive stocks and topical care.

Keywords: Chronic venous ulcer; Healing; Platelet rich plasma; Wounds.