On-Demand Release of Drug from Magnetic Nanoparticle-Loaded Alginate Beads

Dung The Nguyen; Nguyet-Minh Nguyen; Duc-Minh Vu; Minh-Duc Tran; Van-Thao Ta

doi:10.1155/2021/5576283

On-Demand Release of Drug from Magnetic Nanoparticle-Loaded Alginate Beads

J Anal Methods Chem. 2021 Apr 2:2021:5576283. doi: 10.1155/2021/5576283. eCollection 2021.

Authors

Dung The Nguyen¹, Nguyet-Minh Nguyen², Duc-Minh Vu², Minh-Duc Tran², Van-Thao Ta³

Affiliations

¹ Faculty of Chemistry, VNU University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong, Hoan Kiem, Hanoi 11021, Vietnam.
² Nguyen Tat Thanh High School, Hanoi National University of Education, 136 Xuan Thuy, Cau Giay, Hanoi 11310, Vietnam.
³ Department of Medical Engineering, Hanoi Medical University, 1 Ton That Tung, Dong Da, Hanoi 116177, Vietnam.

Abstract

Targeted delivery and controlled release of drugs has been considered to be an important therapeutic approach since it could allow a better treatment efficiency and less side effects. In this research, magnetite Fe₃O₄ nanoparticles were successfully synthesized via the coprecipitation method and then loaded in alginate beads with berberine as a drug model for drug release application. Various factors such as pH values of the suspended environment and surface modifications of the drug carrier could be exploited to adjust the amount of drug release. More importantly, the amount of drug release could be effectively controlled by an on-off switching operation of a static magnetic field.