Nitric oxide sensing revisited

Aloysius Wong; Ningxin Hu; Xuechen Tian; Yixin Yang; Christoph Gehring

doi:10.1016/j.tplants.2021.03.009

Nitric oxide sensing revisited

Trends Plant Sci. 2021 Sep;26(9):885-897. doi: 10.1016/j.tplants.2021.03.009. Epub 2021 Apr 16.

Authors

Aloysius Wong¹, Ningxin Hu², Xuechen Tian², Yixin Yang³, Christoph Gehring⁴

Affiliations

¹ Department of Biology, College of Science and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou, Zhejiang Province 325060, China; Zhejiang Bioinformatics International Science and Technology Cooperation Center, Wenzhou-Kean University, Ouhai, Wenzhou, Zhejiang Province 325060, China. Electronic address: alwong@kean.edu.
² Department of Biology, College of Science and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou, Zhejiang Province 325060, China.
³ Department of Biology, College of Science and Technology, Wenzhou-Kean University, 88 Daxue Road, Ouhai, Wenzhou, Zhejiang Province 325060, China; Zhejiang Bioinformatics International Science and Technology Cooperation Center, Wenzhou-Kean University, Ouhai, Wenzhou, Zhejiang Province 325060, China.
⁴ Department of Chemistry, Biology, and Biotechnology, University of Perugia, I-06121 Perugia, Italy.

PMID: 33867269
DOI: 10.1016/j.tplants.2021.03.009

Abstract

Nitric oxide (NO) sensing is an ancient trait enabled by hemoproteins harboring a highly conserved Heme-Nitric oxide/OXygen (H-NOX) domain that operates throughout bacteria, fungi, and animal kingdoms including in humans, but that has long thought to be absent in plants. Recently, H-NOX-containing plant hemoproteins mediating crucial NO-dependent responses such as stomatal closure and pollen tube guidance have been reported. There are indications that the detection method that led to these discoveries will uncover many more heme-based NO sensors that operate as regulatory sites in complex proteins. Their characterizations will in turn offer a much more complete picture of plant NO responses at both the molecular and systems level.

Keywords: H-NOX; NO sensors; hemoproteins; nitric oxide; nitric oxide signaling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Heme
Hemeproteins*
Nitric Oxide*
Oxygen
Plant Physiological Phenomena*

Substances

Hemeproteins
Nitric Oxide
Heme
Oxygen