Exhaled nitric oxide in premature and mature infants during the first months of life

Fanny E M Goth; Birgitte J Schmidt; Lone Agertoft; Inger Merete Jørgensen

doi:10.1016/j.niox.2021.04.005

Exhaled nitric oxide in premature and mature infants during the first months of life

Nitric Oxide. 2021 Sep 1:113-114:7-12. doi: 10.1016/j.niox.2021.04.005. Epub 2021 Apr 15.

Authors

Fanny E M Goth¹, Birgitte J Schmidt², Lone Agertoft³, Inger Merete Jørgensen⁴

Affiliations

¹ Department of Pediatrics and Adolescence Medicine, Nordsjællands Hospital, Capital Region of Denmark, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark. Electronic address: fanny.edit.maria.goth@regionh.dk.
² Department of Pediatrics, Hvidovre Hospital, Capital Region of Denmark, Denmark.
³ Department of Pediatrics, H.C. Andersen Children's Hospital, Odense University Hospital, University of Southern Denmark, Denmark.
⁴ Department of Pediatrics and Adolescence Medicine, Nordsjællands Hospital, Capital Region of Denmark, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

PMID: 33866006
DOI: 10.1016/j.niox.2021.04.005

Abstract

Aim: In this review, we aim to describe how exhaled Nitric Oxide(NO) changes during the first months of life in premature and mature infants.

Method: Review of the literature up to August 2020, on online, tidal breathing NO measurements in unsedated infants. The association between Fractional exhaled NO(FeNO) values, postnatal age, and prematurity was analysed using linear mixed modeling and Spearman's rank correlation.

Results: Median FeNO during the first months of life was 5.9 and 8.5 ppb in premature and mature infants, respectively. The linear mixed model analysis showed a significant effect of postnatal age on FeNO (p = 0.007).

Conclusion: Our study suggests that FeNO is higher in mature infants than premature infants, and FeNO increased with postnatal age at approximately the same pace in both groups.

Keywords: Exhaled nitric oxide; Lung development; Neonatal; Premature.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Breath Tests*
Exhalation*
Humans
Infant
Nitric Oxide / analysis*

Substances

Nitric Oxide