Identification of novel gankyrin binding scaffolds by high throughput virtual screening

Bioorg Med Chem Lett. 2021 Jul 1:43:128043. doi: 10.1016/j.bmcl.2021.128043. Epub 2021 Apr 16.

Authors

Dipti Kanabar¹, Abbas Kabir¹, Tejashri Chavan¹, Jing Kong¹, Sabesan Yoganathan¹, Aaron Muth²

Affiliations

¹ Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
² Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA. Electronic address: mutha@stjohns.edu.

PMID: 33865970
DOI: 10.1016/j.bmcl.2021.128043

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Benzenesulfonates / chemistry
Benzenesulfonates / pharmacology*
Binding Sites / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Drug Screening Assays, Antitumor
High-Throughput Screening Assays*
Humans
Molecular Structure
Proteasome Endopeptidase Complex / metabolism
Proto-Oncogene Proteins / antagonists & inhibitors*
Proto-Oncogene Proteins / metabolism
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*
Structure-Activity Relationship
Triazoles / chemistry
Triazoles / pharmacology*

Substances

Antineoplastic Agents
Benzenesulfonates
PSMD10 protein, human
Proto-Oncogene Proteins
Small Molecule Libraries
Triazoles
cjoc42 compound
Proteasome Endopeptidase Complex