Association of HMOX-1 with sporadic Alzheimer's disease in southern Han Chinese

Abstract

Background and purpose: The aim of this study was to discover the associations between HMOX-1 and Alzheimer's disease (AD).

Methods: A total of 500 AD patients and 500 healthy controls were recruited in this study. Polymer chain reaction was used.

Results: There was a statistically significant difference between AD patients and controls in both the dominant and recessive models of HMOX-1 rs2071746 after adjustment for age, gender and education (dominant model: p = 0.047, odds ratio [OR] 1.34, 95% confidence interval [CI] 1.00-1.78, adjusted; recessive model: p = 0.049, OR 1.34, 95% CI 1.00-1.80, adjusted). There was also a trend for an association between the dominant model and late-onset AD after adjustment for age, gender and education (dominant model: p = 0.084, OR 1.37, 95% CI 0.96-1.95, adjusted).

Conclusions: We found an association between the dominant and recessive models of HMOX1 rs2071746 and AD.

Keywords: HMOX-1; Alzheimer's disease; genetic associations; late-onset Alzheimer's disease; single nucleotide polymorphism.