The Infant Microbiome and Its Impact on Development of Food Allergy

Kylie N Jungles; Kassidy M Jungles; Leah Greenfield; Mahboobeh Mahdavinia

doi:10.1016/j.iac.2021.01.004

The Infant Microbiome and Its Impact on Development of Food Allergy

Immunol Allergy Clin North Am. 2021 May;41(2):285-299. doi: 10.1016/j.iac.2021.01.004. Epub 2021 Mar 24.

Authors

Kylie N Jungles¹, Kassidy M Jungles², Leah Greenfield³, Mahboobeh Mahdavinia⁴

Affiliations

¹ Department of Pediatrics, University of Michigan C.S. Mott Children's Hospital, 1540 E Hospital Dr #4204, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Allergy and Immunology Division, Rush University Medical Center, 1725 West Harrison Street, Suite 117, Chicago, IL 60612, USA.
² Department of Pharmacology, University of Michigan, 1150 W Medical Center Dr, Ann Arbor, MI 48109, USA.
³ Department of Internal Medicine, Allergy and Immunology Division, Rush University Medical Center, 1725 West Harrison Street, Suite 117, Chicago, IL 60612, USA; Rush Medical College, 600 S Paulina St Suite 524, Chicago, IL 60612, USA.
⁴ Department of Internal Medicine, Allergy and Immunology Division, Rush University Medical Center, 1725 West Harrison Street, Suite 117, Chicago, IL 60612, USA. Electronic address: Mahboobeh_mahdavinia@rush.edu.

PMID: 33863484
DOI: 10.1016/j.iac.2021.01.004

Abstract

The prevalence of food allergy (FA) has been increasing over the past few decades; recent statistics suggest that FA has an impact on up to 10% of the population and 8% of children. Although the pathogenesis of FA is unclear, studies suggest gut microbiome plays a role in the development of FA. The gut microbiome is influenced by infant feeding method, infant diet, and maternal diet during lactation. Breastfeeding, Mediterranean diet, and probiotics are associated with commensal gut microbiota that protect against FA. This area of research is essential to discovering potential preventive methods or therapeutic targets against FA.

Keywords: Food allergy (FA); Gut microbiome; Mediterranean diet; Prevotella copri (P copri).

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Child
Diet
Female
Food Hypersensitivity*
Gastrointestinal Microbiome*
Humans
Infant
Microbiota*
Probiotics*