A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes

Li Yao; Chengmin Yang; Wenjing Zhang; Siyi Li; Qian Li; Lizhou Chen; Su Lui; Graham J Kemp; Bharat B Biswal; Nadim J Shah; Fei Li; Qiyong Gong

doi:10.1016/j.yfrne.2021.100915

A multimodal meta-analysis of regional structural and functional brain alterations in type 2 diabetes

Front Neuroendocrinol. 2021 Jul:62:100915. doi: 10.1016/j.yfrne.2021.100915. Epub 2021 Apr 20.

Authors

Li Yao¹, Chengmin Yang¹, Wenjing Zhang¹, Siyi Li¹, Qian Li¹, Lizhou Chen¹, Su Lui¹, Graham J Kemp², Bharat B Biswal³, Nadim J Shah⁴, Fei Li⁵, Qiyong Gong⁶

Affiliations

¹ Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, NO. 37 Guoxue Xiang, Chengdu 610041, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, NO. 37 Guoxue Xiang, Chengdu 610041, China; Functional and Molecular Imaging Key Laboratory of Sichuan University, NO. 37 Guoxue Xiang, Chengdu 610041, China.
² Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, L3 5TR, United Kingdom.
³ Department of Biomedical Engineering, New Jersey Institute of Technology, 323 Dr Martin Luther King Jr Blvd, Newark, NJ 07102, USA; The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, No.4, Section 2, North Jianshe Road, Chengdu 610054, China.
⁴ Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
⁵ Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, NO. 37 Guoxue Xiang, Chengdu 610041, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, NO. 37 Guoxue Xiang, Chengdu 610041, China; Functional and Molecular Imaging Key Laboratory of Sichuan University, NO. 37 Guoxue Xiang, Chengdu 610041, China; Institute of Neuroscience and Medicine (INM-4), Medical Imaging Physics, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany. Electronic address: charlie_lee@qq.com.
⁶ Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, NO. 37 Guoxue Xiang, Chengdu 610041, China; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, NO. 37 Guoxue Xiang, Chengdu 610041, China; Functional and Molecular Imaging Key Laboratory of Sichuan University, NO. 37 Guoxue Xiang, Chengdu 610041, China. Electronic address: qiyonggong@hmrrc.org.cn.

PMID: 33862036
DOI: 10.1016/j.yfrne.2021.100915

Abstract

Neuroimaging studies have identified brain structural and functional alterations of type 2 diabetes mellitus (T2DM) patients; however, there is no systematic information on the relations between abnormalities in these two domains. We conducted a multimodal meta-analysis of voxel-based morphometry and regional resting-state functional MRI studies in T2DM, including fifteen structural datasets (693 patients and 684 controls) and sixteen functional datasets (378 patients and 358 controls). We found, in patients with T2DM compared to controls, conjoint decreased regional gray matter volume (GMV) and altered intrinsic activity mainly in the default mode network including bilateral superior temporal gyrus/Rolandic operculum, left middle and inferior temporal gyrus, and left supramarginal gyrus; decreased GMV alone in the limbic system; and functional abnormalities alone in the cerebellum, insula, and visual cortex. This meta-analysis identified complicated patterns of conjoint and dissociated brain alterations in T2DM patients, which may help provide new insight into the neuropathology of T2DM.

Keywords: Gray matter volume; Meta-analysis; Multimodal; Resting-state function; Type 2 diabetes mellitus.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / diagnostic imaging
Diabetes Mellitus, Type 2*
Gray Matter / diagnostic imaging
Humans
Magnetic Resonance Imaging
Neuroimaging