Founder cells shape brain evolution

Jing Liu; Debra L Silver

doi:10.1016/j.cell.2021.03.045

Founder cells shape brain evolution

Cell. 2021 Apr 15;184(8):1965-1967. doi: 10.1016/j.cell.2021.03.045.

Authors

Jing Liu¹, Debra L Silver²

Affiliations

¹ Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
² Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Departments of Cell Biology and Neurobiology, Duke Institute of Brain Sciences, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: debra.silver@duke.edu.

PMID: 33861961
DOI: 10.1016/j.cell.2021.03.045

Abstract

Humans have an extraordinarily expanded and complex cerebral cortex, relative to non-human primates. Yet the mechanisms underlying cortical differences across evolution are unclear. A new study by Benito-Kwiecinski et al. employs cerebral organoids derived across great apes to implicate neuroepithelial progenitor shape transitions in human cortical expansion.

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MeSH terms

Animals
Brain
Cerebral Cortex
Hominidae*
Organoids*
Primates