At least two to tango: Choreographing chromatin through cooperative footprints

Nour J Abdulhay; Vijay Ramani

doi:10.1016/j.molcel.2021.03.022

At least two to tango: Choreographing chromatin through cooperative footprints

Mol Cell. 2021 Apr 15;81(8):1591-1593. doi: 10.1016/j.molcel.2021.03.022.

Authors

Nour J Abdulhay¹, Vijay Ramani²

Affiliations

¹ Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. Electronic address: nour.abdulhay@ucsf.edu.
² Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA; Bakar Computational Health Sciences Institute, San Francisco, CA, USA. Electronic address: vijay.ramani@ucsf.edu.

PMID: 33861946
DOI: 10.1016/j.molcel.2021.03.022

Abstract

Two recent papers, Rao et al. (2021), in this issue, and Sönmezer et al. (2021), investigate transcription factor cooperativity at cis-regulatory elements. Using data from nuclease- and methyltransferase-footprinting experiments, they demonstrate that factor co-occupancy at regulatory elements commonly occurs in vivo and is conserved from fly to mouse.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Chromatin* / genetics
Gene Expression Regulation
Mice
Protein Binding
Regulatory Sequences, Nucleic Acid
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Chromatin
Transcription Factors