A complete, gauge-invariant computation of two-loop virtual corrections involving closed fermion loops to the polarized Møller scattering asymmetry is presented. The set of contributions involving two closed fermion loops and the set involving one closed fermion loop are numerically similar in magnitude to the one-loop bosonic corrections and yield an overall correction of 1.3% relative to the tree level asymmetry. We estimate sizes of the remaining two-loop contributions and discuss implications for the upcoming MOLLER (Measurement of a Lepton-Lepton Electroweak Reaction) experiment.