Within the Late Pleistocene, terminations describe the major transitions marking the end of glacial cycles. While it is established that abrupt shifts in the ocean/atmosphere system are a ubiquitous component of deglaciation, significant uncertainties remain concerning their specific role and the likelihood that terminations may be interrupted by large-amplitude abrupt oscillations. In this perspective we address these uncertainties in the light of recent developments in the understanding of glacial terminations as the ultimate interaction between millennial and orbital timescale variability. Innovations in numerical climate simulation and new geologic records allow us to highlight new avenues of research and identify key remaining uncertainties such as sea-level variability.