Metastatic squamous cell carcinoma of the colon: a conundrum in colorectal malignancies

BMJ Case Rep. 2021 Apr 15;14(4):e240573. doi: 10.1136/bcr-2020-240573.

Abstract

Small-cell carcinoma of the colon is an extremely rare tumour, with poorly understood pathogenesis and unestablished treatment guidelines. The first case was documented in 1919, and only about 100 cases of this condition have been reported to this date. In this case report, we present a case of sigmoid squamous cell carcinoma that eventually led to bowel perforation and was diagnosed on histopathology after emergent surgical intervention. Additionally, we also review the incidence, epidemiology, pathogenesis, immunohistological markers, neogenomics and therapeutic strategies for the same.

Keywords: cancer intervention; colon cancer; oncology.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Squamous Cell* / surgery
  • Colon, Sigmoid
  • Colorectal Neoplasms*
  • Humans
  • Intestinal Perforation*