Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum

Fan Yang; Qiang Hua; Li-Gong Yao; Lin-Fu Liang; Yan-Hua Lu; Fa-Liang An; Yue-Wei Guo

doi:10.1016/j.fitote.2021.104906

Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum

Fitoterapia. 2021 Jun:151:104906. doi: 10.1016/j.fitote.2021.104906. Epub 2021 Apr 12.

Authors

Fan Yang¹, Qiang Hua², Li-Gong Yao³, Lin-Fu Liang⁴, Yan-Hua Lu², Fa-Liang An⁵, Yue-Wei Guo⁶

Affiliations

¹ State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China; Biology Department, College of Life and Environment Science, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, People's Republic of China.
² State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China.
³ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
⁴ College of Materials Science and Engineering, Central South University of Forestry and Technology, 498 South Shaoshan Road, Changsha 410004, China.
⁵ State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China; Shanghai Collaborative Innovation Center for Biomanufacturing Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China. Electronic address: flan2016@ecust.edu.cn.
⁶ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China. Electronic address: ywguo@simm.ac.cn.

PMID: 33857589
DOI: 10.1016/j.fitote.2021.104906

Abstract

Further chemical investigation of the Xisha soft coral Litophyton nigrum has resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely linardosinenes D-G (1-4). The structures of new compounds were elucidated by extensive analyses of their spectroscopic data and by comparison with the reported data of known related ones. All compounds exhibited weak inhibitory effect against bromodomain-containing protein 4 (BRD4), a promising therapeutic target in various human diseases, at a concentration of 10 μM.

Keywords: Litophyton nigrum; Nardosinane; Soft coral.

MeSH terms

Animals
Anthozoa / chemistry*
Biological Products / pharmacology*
Cell Cycle Proteins / antagonists & inhibitors*
China
Humans
Molecular Structure
Pacific Ocean
Sesquiterpenes / pharmacology*
Transcription Factors / antagonists & inhibitors*

Substances

BRD4 protein, human
Biological Products
Cell Cycle Proteins
Sesquiterpenes
Transcription Factors