Endogenous formaldehyde destroys blood stem cells

Blood. 2021 Apr 15;137(15):1988-1990. doi: 10.1182/blood.2020010541.

Abstract

In this issue of Blood, Mu et al show that induced pluripotent stem cells (iPSCs) derived from patients with novel inherited bone marrow failure syndrome (IBMFS), alcohol dehydrogenase 5 (ADH5)/aldehyde dehydrogenase 2 (ALDH2) deficiency, fail to produce hematopoietic progenitors.

Publication types

  • Comment

MeSH terms

  • Formaldehyde*
  • Stem Cells*

Substances

  • Formaldehyde