Objective: To review the research progress of the clinical application of the medial sural artery perforator flap (MSAPF).
Methods: The relevant domestic and abroad literature on the clinical application of MSAPF was extensively consulted, and the research progress were summarized and analyzed in aspect of its definition, anatomical characteristics, clinical application, surgical resection and improvement, and advantages and disadvantages of flaps, etc.
Results: MSAPF has the advantages of relatively constant anatomical position, thin flap texture, long vascular pedicle, large vessel diameter, no sacrifice of main blood vessels, concealed donor site, no hair, and fewer complications; it can carry nerves, tendons, and muscles to construct chimeric flaps to repair three-dimensional wounds; and can also repair wounds with high aesthetic and functional requirements such as hand, foot and ankle, head and neck, etc.
Conclusion: The MSAPF is a versatile, various forms, functional diversification, and three-dimensional flap donor site with various application forms and ideal repair effectiveness.
目的: 对腓肠内侧动脉穿支皮瓣（medial sural artery perforator flap，MSAPF）临床应用研究进展进行综述。.
方法: 广泛查阅国内外关于 MSAPF 临床应用的相关文献，对其定义、解剖学特点、临床应用、手术切取和改良、皮瓣优缺点等方面进行总结分析。.
结果: MSAPF 具有血管解剖位置相对恒定、皮瓣质地薄、血管蒂长、管径粗大、不牺牲主干血管、供区隐蔽、无毛发、并发症少等优点；可携带神经、肌腱、肌肉构建嵌合皮瓣修复三维软组织缺损创面，也可修复手部、足踝、头颈面部等对外观及功能要求较高的创面。.
结论: MSAPF 应用方法多样，修复效果理想，是一种多用途、多形式、多功能、可三维应用的皮瓣供区。.
Keywords: Medial sural artery perforator flap; defect reconstruction; microsurgery.