High-dose glucocorticoid treatment of near-fatal bocavirus lung infection results in rapid recovery

Matthias Obenaus; Oliver Schildgen; Dirk Schürmann; Ann-Christin von Brünneck; Martin Janz; Ulrich Keller; Bernhard Gebauer; Johannes Schilling; Stefan Schwartz; Benedikt Weissbrich; Thomas Schneider; Jörg Hofmann; Stephan Mathas

doi:10.1183/23120541.00060-2021

High-dose glucocorticoid treatment of near-fatal bocavirus lung infection results in rapid recovery

ERJ Open Res. 2021 Apr 12;7(2):00060-2021. doi: 10.1183/23120541.00060-2021. eCollection 2021 Apr.

Authors

Affiliations

¹ Hematology, Oncology and Tumor Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
² Institute of Pathology, Kliniken der Stadt Köln gGmbH, Kliniken der Privaten Universität Witten/Herdecke mit Sitz in Köln, Cologne, Germany.
³ Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁴ Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁵ Experimental and Clinical Research Center, a cooperation between the Charité and the Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
⁶ Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁷ Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁸ Institute for Virology and Immunbiology, University Würzburg, Würzburg, Germany.
⁹ Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
¹⁰ Institute of Virology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Abstract

Human bocavirus (HBoV) has to be considered a life-threatening pathogen in adults with atypical pneumonia. Pulsed high-dose glucocorticoid treatment may be beneficial in patients suffering from severe pulmonary disease caused by HBoV or other viruses. https://bit.ly/3epiMyO.