Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl42- complex

Honoka Obata; Katsuyuki Minegishi; Kotaro Nagatsu; Mikako Ogawa; Ming-Rong Zhang

doi:10.1038/s41598-021-87576-2

Synthesis of no-carrier-added [^{188, 189, 191}Pt]cisplatin from a cyclotron produced ^{188, 189, 191}PtCl₄^2- complex

Sci Rep. 2021 Apr 14;11(1):8140. doi: 10.1038/s41598-021-87576-2.

Authors

Honoka Obata^{1

2

3}, Katsuyuki Minegishi¹, Kotaro Nagatsu⁴, Mikako Ogawa², Ming-Rong Zhang¹

Affiliations

¹ Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science (iQMS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.
² Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Hokkaido, 060-0812, Japan.
³ Japan Society for the Promotion of Science (JSPS), 5-3-1 Kojimachi, Chiyoda-ku, Tokyo, 102-0083, Japan.
⁴ Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science (iQMS), National Institutes for Quantum and Radiological Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan. nagatsu.kotaro@qst.go.jp.

Abstract

We developed a novel method for production of no-carrier-added (n.c.a.) [^{188, 189, 191}Pt]Pt^IICl₄^2- from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[Pt^IICl₂(NH₃)₂] ([*Pt]cisplatin) from [*Pt]Pt^IICl₄^2-. [*Pt]Pt^IICl₄^2- was prepared as a synthetic precursor of n.c.a. *Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of Ir^IVCl₆^2- with ascorbic acid. The ligand-substitution reaction of Cl with NH₃ was promoted by treating n.c.a. [*Pt]Pt^IICl₄^2- with excess NH₃ and heating the reaction mixture, and n.c.a. [*Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [*Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99 + % at the end of synthesis (EOS).

Publication types

Research Support, Non-U.S. Gov't