Setting molecular traps in yeast for identification of anticancer drug targets

Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2105547118. doi: 10.1073/pnas.2105547118.

Authors

Grant W Brown^{1

2}, Brenda Andrews^{1

3}

Affiliations

¹ The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada; grant.brown@utoronto.ca brenda.andrews@utoronto.ca.
² Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada.
³ Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
DNA Repair / drug effects
DNA-Binding Proteins / chemistry
DNA-Binding Proteins / genetics*
Drug Delivery Systems
Flap Endonucleases / antagonists & inhibitors
Flap Endonucleases / genetics*
Homologous Recombination / drug effects
Humans
Multiprotein Complexes / genetics
Neoplasms / drug therapy*
Neoplasms / genetics
Parthanatos / drug effects
Poly (ADP-Ribose) Polymerase-1 / genetics
Saccharomyces cerevisiae / genetics
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*
Synthetic Lethal Mutations / drug effects
Synthetic Lethal Mutations / genetics*

Substances

Antineoplastic Agents
DNA-Binding Proteins
Multiprotein Complexes
Small Molecule Libraries
PARP1 protein, human
Poly (ADP-Ribose) Polymerase-1
Flap Endonucleases
FEN1 protein, human

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