Short-, Mid-, and Long-Term Associations Between PM2.5 and Stroke Incidence in Taiwan

Chun-Pai Yang; Chung-Yi Li; Winn-Jung Huang; Hwa-Lung Yu; Cheng-Chia Yang; Mei-Chun Lu; Hui-Chu Lang; Yuan-Horng Yan

doi:10.1097/JOM.0000000000002222

Short-, Mid-, and Long-Term Associations Between PM2.5 and Stroke Incidence in Taiwan

J Occup Environ Med. 2021 Sep 1;63(9):742-751. doi: 10.1097/JOM.0000000000002222.

Authors

Chun-Pai Yang¹, Chung-Yi Li, Winn-Jung Huang, Hwa-Lung Yu, Cheng-Chia Yang, Mei-Chun Lu, Hui-Chu Lang, Yuan-Horng Yan

Affiliation

¹ From the Department of Neurology (Dr Yang); Department of Medical Research (Dr Yang, Ms Lu, Dr Yan), Kuang Tien General Hospital, Taichung, Taiwan; Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan (Dr Yang, Dr Yan); Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan (Dr Li); Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan (Dr Li); Department of Safety, Health, and Environmental Engineering, Hung Kuang University, Taichung, Taiwan (Dr Huang); Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan (Dr Yu); Department of Healthcare Administration, Asia University, Taichung, Taiwan (Dr Yang); Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan (Dr Lang); National Yang Ming Chiao Tung University, Taipei, Taiwan (Dr Lang); Department of Endocrinology and Metabolism, Kuang Tien General Hospital, Taichung, Taiwan (Dr Yan).

PMID: 33852547
DOI: 10.1097/JOM.0000000000002222

Abstract

Objective: To investigate the association between the risk of stroke and exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM2.5) over various exposure periods.

Methods: This was a nationwide population-based case-control study in which 10,035 incident patients with a primary diagnosis of ischemic stroke each were matched with two randomly selected controls for sex, age, Charlson Comorbidity Index, year of stroke diagnosis, and level of urbanization. Multiple logistic models adjusted for potential confounders were used to assess the association of PM2.5 with ischemic stroke incidence.

Results: There were significant short-term, medium-term, and long-term relationships between PM2.5 exposure and ischemic stroke incidence.

Conclusions: This study supports existing evidence that PM2.5 should be considered a risk factor for ischemic stroke.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Air Pollutants* / adverse effects
Air Pollutants* / analysis
Air Pollution* / adverse effects
Air Pollution* / analysis
Case-Control Studies
Environmental Exposure / analysis
Humans
Incidence
Particulate Matter / adverse effects
Particulate Matter / analysis
Stroke* / epidemiology
Taiwan / epidemiology

Substances

Air Pollutants
Particulate Matter