Discovery of Oligosaccharide Antigens for Semi-Synthetic Glycoconjugate Vaccine Leads against Streptococcus suis Serotypes 2, 3, 9 and 14*

Angew Chem Int Ed Engl. 2021 Jun 21;60(26):14679-14692. doi: 10.1002/anie.202103990. Epub 2021 May 19.

Abstract

Streptococcus suis bacteria are one of the most serious health problems for pigs and an emerging zoonotic agent in humans working in the swine industry. S. suis bacteria express capsular polysaccharides (CPS) a major bacterial virulence factor that define the serotypes. Oligosaccharides resembling the CPS of S. suis serotypes 2, 3, 9, and 14 have been synthesized, glycans related to serotypes 2 and 9 were placed on glycan array surfaces to screen blood from infected pigs. Lead antigens for the development of semi-synthetic S. suis serotypes 2 and 9 glycoconjugate veterinary vaccines were identified in this way.

Keywords: carbohydrates; glycans; immunology; oligosaccharides; total synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / immunology
  • Anti-Bacterial Agents / pharmacology*
  • Antigens / chemistry
  • Antigens / immunology*
  • Drug Discovery
  • Glycoconjugates / chemistry
  • Glycoconjugates / immunology
  • Glycoconjugates / pharmacology*
  • Polysaccharides, Bacterial / chemistry
  • Polysaccharides, Bacterial / immunology*
  • Streptococcus suis / drug effects*
  • Vaccines, Synthetic / chemistry
  • Vaccines, Synthetic / immunology
  • Vaccines, Synthetic / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Antigens
  • Glycoconjugates
  • Polysaccharides, Bacterial
  • Vaccines, Synthetic