Resveratrol is an inhibitor of sodium-dependent inorganic phosphate transport in triple-negative MDA-MB-231 breast cancer cells

Abstract

Metastasis is a major cause of death in patients with breast cancer. A growing body of evidence has demonstrated the antitumour effects of resveratrol, a non-flavonoid polyphenol. Resveratrol inhibits metastatic processes, such as the migration and invasion of cancer cells. In several cancer types, the importance of inorganic phosphate (Pi) for tumor progression has been demonstrated. The metastatic process in breast cancer is associated with Na⁺ -dependent Pi transporters. In this study, we demonstrate, for the first time, that resveratrol inhibits the Na⁺ -dependent Pi transporter. Results from kinetic analysis shows that resveratrol inhibits Na⁺ -dependent Pi transport non-competitively. Resveratrol also inhibits adhesion/migration in MDA-MB-231 cells, likely related to inhibition of the Na⁺ -dependent Pi transporter.

Keywords: MDA-MB-231 cell; Pi uptake; breast cancer; metastasis; migration; resveratrol.