Novel double beta-lactam therapy for Granulicatella adiacens infective endocarditis

S Khan; C Urban; V Singh; D Liu; S Segal-Maurer; Y Parmar; J Yoon

doi:10.1016/j.idcr.2021.e01082

Novel double beta-lactam therapy for Granulicatella adiacens infective endocarditis

IDCases. 2021 Mar 24:24:e01082. doi: 10.1016/j.idcr.2021.e01082. eCollection 2021.

Authors

S Khan¹, C Urban^{1

2}, V Singh³, D Liu³, S Segal-Maurer^{1

2}, Y Parmar⁴, J Yoon¹

Affiliations

¹ The Dr. James J. Rahal, Jr. Division of Infectious Diseases, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA.
² Weill Cornell Medical College, Cornell University, NY, 10065, USA.
³ Department of Pathology, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA.
⁴ Department of Cardiology, NewYork-Presbyterian Queens, 56-45 Main Street, Flushing, NY, 11355, USA.

Abstract

Granulicatella adiacens, a nutritionally variant streptococci (NVS) is a well described organism associated with endocarditis. Previously communicated cases have documented the use of double beta-lactam therapy with ampicillin and ceftriaxone to treat patients with infective endocarditis due to Enterococcus faecalis and Streptocossus pneumoniae. We describe the first case of Granulicatella adiacens infective endocarditis in a patient successfully treated with the combination of intravenous ampicillin and ceftriaxone and document their synergistic activity.

Keywords: Double beta-lactam therapy; Granulicatella adiacens; Infective endocarditis; Synergy.

Publication types

Case Reports