Interventional bronchoscopy for HPV 16 and 66 with the use of spraying interferon-α (2b) plus bevacizumab and anti-reflux agent

Paul Zarogoulidis; Dimitris Hatzibougias; Kosmas Tsakiridis; Wolfgang Hohenforst-Schmidt; Haidong Huang; Chong Bai; Nikos Kougas; Anastasios Vagionas; Stavros Tryfon; Maria Saroglou; Lutz Freitag; Christoforos Kosmidis; Aimilios Lallas; Dimitris Matthaios; Chrisanthi Sardeli

doi:10.1016/j.rmcr.2021.101398

Interventional bronchoscopy for HPV 16 and 66 with the use of spraying interferon-α (2b) plus bevacizumab and anti-reflux agent

Respir Med Case Rep. 2021 Mar 19:33:101398. doi: 10.1016/j.rmcr.2021.101398. eCollection 2021.

Authors

Paul Zarogoulidis^{1

2}, Dimitris Hatzibougias³, Kosmas Tsakiridis⁴, Wolfgang Hohenforst-Schmidt⁵, Haidong Huang⁶, Chong Bai⁶, Nikos Kougas⁷, Anastasios Vagionas⁸, Stavros Tryfon⁹, Maria Saroglou⁹, Lutz Freitag¹⁰, Christoforos Kosmidis², Aimilios Lallas¹¹, Dimitris Matthaios¹², Chrisanthi Sardeli¹³

Affiliations

¹ 3rd University General Hospital, "AHEPA" University Hospital, Thessaloniki, Greece.
² Pulmonary Department, "Bioclinic" Private Clinic, Thessaloniki, Greece.
³ Microdiagnostics Private Pathology Laboratory, Thessaloniki, Greece.
⁴ Thoracic Surgery Department, "Interbalkan" European Medical Center, Thessaloniki, Greece.
⁵ Sana Clinic Group Franken, Department of Cardiology, Pulmonology, Intensive Care, Nephrology, "Hof" Clinics, University of Erlangen, Hof, Germany.
⁶ Department of Respiratory & Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, PR China.
⁷ Rheumatology Department, "Hippokratio" University Hospital, Thessaloniki, Greece.
⁸ Oncology Department, General Hospital of Kavala, Kavala, Greece.
⁹ Pulmonary Department (NHS), "G. Papanikolaou" General Hospital, Thessaloniki, Greece.
¹⁰ Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.
¹¹ First Dermatology Department, Aristotle University of Thessaloniki, Thessaloniki, Greece.
¹² Oncology Department, General Hospital of Rhodos, Rhodos, Greece.
¹³ Department of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Abstract

A fifty year old male was diagnosed with bronchial HPV. He was treated with local interventional treatment argon plasma coagulation and subcutaneous injections bevacizumab. Spraying of the regions followed with a specially designed catheter with interferon-α (2b). Systematic treatment of esomeprazole was also administered. After six months the patient is disease free and on close follow-up.

Keywords: APC; Bronchoscopy; HPV; IL-17; Instillation; Laser.

Publication types

Case Reports