Abdominal tuberculosis in a tertiary care centre in Saudi Arabia

Indian J Tuberc. 2021 Apr;68(2):236-241. doi: 10.1016/j.ijtb.2020.09.007. Epub 2020 Sep 12.

Abstract

Objectives: Abdominal tuberculosis (ATB) is the second most common type of extra-pulmonary tuberculosis. Though it does not usually pose a significant risk of infectivity, ATB can go unidentified and progress to disseminated infection. The aim of this study is to highlight the incidence and outcome of this infection in a tertiary care centre in the Kingdom of Saudi Arabia (KSA).

Methods: In this retrospective study, we included all ATB patients admitted to our centre between January 1 st, 2010 and December 31, 2018. A total of 42 patients with a median age of 49 (range 18-83 years, 78.6% males) were identified.

Results: The most common presentation was abdominal pain, weight loss, and abdominal distension. All the patients were HIV negative; however, 50% had a comorbid condition, mainly diabetes mellitus, chronic renal failure, and liver cirrhosis. Tuberculous peritonitis was the predominant type of ATB. Suspicious and potentially malignant abdominal masses appeared on the abdominal CT scans of six patients. This suggest that TB should be excluded in patients from endemic area presenting with abdominal masses. All patients received standard anti-tuberculous medication for an average duration of 7.4 months. The outcome was excellent with 88%% achieving complete response. Adjunctive corticosteroids were not used, and none of the patients had a surgical complication.

Conclusion: The diagnosis of ATB is challenging. It can mimic inflammatory bowel disease in young populations and malignancy in middle-aged and elderly population. For this reason, a high index of suspicion with prompt treatment is required to improve the prognosis and prevent complications.

Keywords: Abdominal; CA-125; Laparoscopy; Mycobacterium tuberculosis (MTB); Tuberculosis.

MeSH terms

  • Abdomen
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / metabolism
  • CA-125 Antigen / metabolism
  • Dietary Supplements
  • Female
  • Humans
  • Incidence
  • Male
  • Medical Records
  • Middle Aged
  • Retrospective Studies
  • Saudi Arabia / epidemiology
  • Tertiary Care Centers
  • Tuberculosis, Gastrointestinal / diagnosis
  • Tuberculosis, Gastrointestinal / drug therapy
  • Tuberculosis, Gastrointestinal / epidemiology*
  • Tuberculosis, Gastrointestinal / metabolism
  • Vitamin D
  • Young Adult

Substances

  • Biomarkers
  • CA-125 Antigen
  • Vitamin D