EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel

Claudio Babiloni; Xianghong Arakaki; Laura Bonanni; Ana Bujan; Maria C Carrillo; Claudio Del Percio; Rebecca M Edelmayer; Gary Egan; Fanny M Elahh; Alan Evans; Raffaele Ferri; Giovanni B Frisoni; Bahar Güntekin; Atticus Hainsworth; Harald Hampel; Vesna Jelic; Jaeseung Jeong; Doh Kwan Kim; Milica Kramberger; Sanjeev Kumar; Roberta Lizio; Flavio Nobili; Giuseppe Noce; Aina Puce; Petra Ritter; Dirk J A Smit; Andrea Soricelli; Stefan Teipel; Federico Tucci; Perminder Sachdev; Mitchell Valdes-Sosa; Pedro Valdes-Sosa; Andrea Vergallo; Görsev Yener

doi:10.1016/j.neurobiolaging.2021.03.003

EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel

Neurobiol Aging. 2021 Jul:103:78-97. doi: 10.1016/j.neurobiolaging.2021.03.003. Epub 2021 Mar 10.

Authors

Claudio Babiloni¹, Xianghong Arakaki², Laura Bonanni³, Ana Bujan⁴, Maria C Carrillo⁵, Claudio Del Percio⁶, Rebecca M Edelmayer⁵, Gary Egan⁷, Fanny M Elahh⁸, Alan Evans⁹, Raffaele Ferri¹⁰, Giovanni B Frisoni¹¹, Bahar Güntekin¹², Atticus Hainsworth¹³, Harald Hampel¹⁴, Vesna Jelic¹⁵, Jaeseung Jeong¹⁶, Doh Kwan Kim¹⁷, Milica Kramberger¹⁸, Sanjeev Kumar¹⁹, Roberta Lizio²⁰, Flavio Nobili²¹, Giuseppe Noce²⁰, Aina Puce²², Petra Ritter²³, Dirk J A Smit²⁴, Andrea Soricelli²⁵, Stefan Teipel²⁶, Federico Tucci⁶, Perminder Sachdev²⁷, Mitchell Valdes-Sosa²⁸, Pedro Valdes-Sosa²⁹, Andrea Vergallo¹⁴, Görsev Yener³⁰

Affiliations

¹ Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy; San Raffaele Cassino, Cassino, FR, Italy. Electronic address: claudio.babiloni@uniroma1.it.
² Huntington Medical Research Institutes, Pasadena, CA, USA.
³ Department of Neuroscience Imaging and Clinical Sciences and CESI, University G D'Annunzio of Chieti-Pescara, Chieti, Italy.
⁴ Psychological Neuroscience Lab, School of Psychology, University of Minho, Portugal.
⁵ Alzheimer's Association, Chicago, IL, USA.
⁶ Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Rome, Italy.
⁷ Foundation Director of the Monash Biomedical Imaging (MBI) research facilities, Monash University, Clayton, Australia.
⁸ Memory and Aging Center, University of California, San Francisco.
⁹ Department of Neurology and Neurosurgery, McGill University, Montreal, Canada.
¹⁰ Oasi Research Institute - IRCCS, Troina, EN, Italy.
¹¹ Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland; Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
¹² Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey; REMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Lab, Istanbul Medipol University, Istanbul, Turkey.
¹³ University of London St George's Molecular and Clinical Sciences Research Institute, London, UK.
¹⁴ Sorbonne University, GRC No. 21, Alzheimer Precision Medicine, Pitié-Salpêtrière Hospital, Paris, France.
¹⁵ Division of Clinical Geriatrics, NVS Department, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
¹⁶ Department of Bio and Brain Engineering/Program of Brain and Cognitive Engineering Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.
¹⁷ Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.
¹⁸ Center for cognitive and movement disorders, Department of neurology, University Medical Center Ljubljana, Slovenia.
¹⁹ Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
²⁰ IRCCS SDN, Naples, Italy.
²¹ Clinica neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy; Dipartimento di Neuroscienze, Oftalmologia, Genetica, Riabilitazione e Scienze Materno-infantili (DiNOGMI).
²² Department of Psychological and Brain Sciences at Indiana University in Bloomington, Indiana, USA.
²³ Brain Simulation Section, Department of Neurology, Charité Universitätsmedizin and Berlin Institute of Health, Berlin, Germany; Bernstein Center for Computational Neuroscience, Berlin, Germany.
²⁴ Department of Psychiatry Academisch Medisch Centrum Universiteit van Amsterdam, Amsterdam, the Netherlands.
²⁵ IRCCS SDN, Naples, Italy; Department of Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy.
²⁶ Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; German Center for Neurodegenerative Diseases (DZNE) - Rostock/Greifswald, Rostock, Germany.
²⁷ Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales; Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, Australia.
²⁸ Cuban Neuroscience Center, Havana, Cuba.
²⁹ Cuban Neuroscience Center, Havana, Cuba; Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
³⁰ Izmir Biomedicine and Genome Center. Dokuz Eylul University Health Campus, Izmir, Turkey.

PMID: 33845399
DOI: 10.1016/j.neurobiolaging.2021.03.003

Abstract

Vascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A multidisciplinary expert panel reviewed the clinical literature and reached consensus about the EEG measures consistently found as abnormal in VCI patients with dementia. As compared to cognitively unimpaired individuals, those VCI patients showed (1) smaller amplitude of resting state alpha (8-12 Hz) rhythms dominant in posterior regions; (2) widespread increases in amplitude of delta (< 4 Hz) and theta (4-8 Hz) rhythms; and (3) delayed N200/P300 peak latencies in averaged event-related potentials, especially during the detection of auditory rare target stimuli requiring participants' responses in "oddball" paradigms. The expert panel formulated the following recommendations: (1) the above EEG measures are not specific for VCI and should not be used for its diagnosis; (2) they may be considered as "neural synchronization" biomarkers to enlighten the relationships between features of the VCI-related cerebrovascular lesions and abnormalities in neurophysiological brain mechanisms; and (3) they may be tested in future clinical trials as prognostic biomarkers and endpoints of interventions aimed at normalizing background brain excitability and vigilance in wakefulness.

Keywords: Cerebrovascular disease (CVD); Event-related oscillations (EROs); Event-related potentials (ERPs); Resting state electroencephalographic (rsEEG) rhythms; Small vessel disease; Subcortical ischemic vascular disease; Vascular cognitive impairment (VCI); Vascular contribution to cognitive impairment and dementia (VCID); Vascular dementia (VaD).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / physiopathology*
Cognitive Dysfunction / diagnosis*
Cognitive Dysfunction / etiology
Cognitive Dysfunction / physiopathology
Dementia, Vascular / diagnosis*
Dementia, Vascular / etiology
Dementia, Vascular / physiopathology
Electroencephalography / methods*
Evoked Potentials / physiology
Humans
Rest / physiology

Abstract

Publication types

MeSH terms

Grants and funding