Pitx genes in development and disease

Cell Mol Life Sci. 2021 Jun;78(11):4921-4938. doi: 10.1007/s00018-021-03833-7. Epub 2021 Apr 12.

Abstract

Homeobox genes encode sequence-specific transcription factors (SSTFs) that recognize specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential in specifying spatial and temporal cell identity and as a result, their mutations often cause severe developmental defects. Pitx genes belong to the PRD class of the highly evolutionary conserved homeobox genes in all animals. Vertebrates possess three Pitx paralogs, Pitx1, Pitx2, and Pitx3 while non-vertebrates have only one Pitx gene. The ancient role of regulating left-right (LR) asymmetry is conserved while new functions emerge to afford more complex body plan and functionalities. In mouse, Pitx1 regulates hindlimb tissue patterning and pituitary development. Pitx2 is essential for the development of the oral cavity and abdominal wall while regulates the formation and symmetry of other organs including pituitary, heart, gut, lung among others by controlling growth control genes upon activation of the Wnt/ß-catenin signaling pathway. Pitx3 is essential for lens development and migration and survival of the dopaminergic neurons of the substantia nigra. Pitx gene mutations are linked to various congenital defects and cancers in humans. Pitx gene family has the potential to offer a new approach in regenerative medicine and aid in identifying new drug targets.

Keywords: Development; Disease; Evolution; Homeobox genes; Pitx.

Publication types

  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Biological Evolution
  • Embryonic Development / genetics
  • Genetic Diseases, Inborn / genetics
  • Genetic Diseases, Inborn / pathology*
  • Humans
  • Organogenesis
  • Paired Box Transcription Factors / classification
  • Paired Box Transcription Factors / genetics
  • Paired Box Transcription Factors / metabolism*
  • Regenerative Medicine
  • Wnt Signaling Pathway

Substances

  • Paired Box Transcription Factors