A Fast Transform for Brain Connectivity Difference Evaluation

Neuroinformatics. 2022 Apr;20(2):285-299. doi: 10.1007/s12021-021-09518-7. Epub 2021 Apr 12.

Abstract

Anatomical and dynamical connectivity are essential to healthy brain function. However, quantifying variations in connectivity across conditions or between patient populations and appraising their functional significance are highly non-trivial tasks. Here we show that link ranking differences induce specific geometries in a convenient auxiliary space that are often easily recognisable at mere eye inspection. Link ranking can also provide fast and reliable criteria for network reconstruction parameters for which no theoretical guideline has been proposed.

Keywords: Alzheimer’s disease; Complex networks; Functional brain connectivity; Link difference ranking; Schizophrenia.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alzheimer Disease*
  • Brain / diagnostic imaging
  • Brain Mapping
  • Head
  • Humans
  • Magnetic Resonance Imaging
  • Nerve Net / diagnostic imaging
  • Neural Pathways / diagnostic imaging