A narrative review of the mechanism of acute pancreatitis and recent advances in its clinical management

Zhi Zheng; Yi-Xuan Ding; Yuan-Xu Qu; Feng Cao; Fei Li

A narrative review of the mechanism of acute pancreatitis and recent advances in its clinical management

Am J Transl Res. 2021 Mar 15;13(3):833-852. eCollection 2021.

Authors

Zhi Zheng^{1

2}, Yi-Xuan Ding^{1

2}, Yuan-Xu Qu^{1

2}, Feng Cao^{1

2}, Fei Li^{1

2}

Affiliations

¹ Department of General Surgery, Xuan Wu Hospital, Capital Medical University Beijing 100053, China.
² Clinical Center for Acute Pancreatitis, Capital Medical University Beijing, China.

PMID: 33841625
PMCID: PMC8014344

Abstract

Acute pancreatitis (AP) is a common gastrointestinal disease with a high risk of mortality. Recently, the exosome and its potential regulatory role in the progression of AP has garnered the interest of researchers. However, effective drug interventions and therapeutic targets for AP remain to be established. Treatment approaches for AP have undergone considerable changes in the recent years: there is a greater preference for minimally invasive therapy (as primary treatment), multidisciplinary participation and the step-up approach. We aimed to discuss AP mechanism and the recent advancement in its treatment strategies to manage AP better in clinical practice.

Keywords: Acute pancreatitis; clinical practice; exosome; follow-up; mechanism.

Publication types

Review