Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection

Chia-Jung Kuo; Cheng-Han Lee; Ming-Ling Chang; Cheng-Yu Lin; Wey-Ran Lin; Ming-Yao Su; Cheng-Hsun Chiu; Chi-Nan Tseng; Yu-Shan Wu; Cheng-Tang Chiu; Chih-Ho Lai

doi:10.1016/j.jmii.2021.03.006

Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection

J Microbiol Immunol Infect. 2021 Dec;54(6):1184-1187. doi: 10.1016/j.jmii.2021.03.006. Epub 2021 Mar 23.

Authors

Affiliations

¹ Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
² Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
³ Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
⁴ Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Gastroenterology and Hepatology, New Taipei Municipal Tucheng Hospital, New Taipei, Taiwan.
⁵ College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
⁶ Department of Cardiothoracic and Vascular Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
⁷ Department of Laboratory Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
⁸ Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address: ctchiu@adm.cgmh.org.tw.
⁹ Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Microbiology and Immunology, Chang Gung University, Taoyuan, Taiwan; Department of Nursing, Asia University, Taichung, Taiwan; Department of Medical Research, School of Medicine, China Medical University and Hospital, Taichung, Taiwan. Electronic address: chlai@mail.cgu.edu.tw.

PMID: 33840604
DOI: 10.1016/j.jmii.2021.03.006

Abstract

This study investigated the antimicrobial resistance of isolates from patients with refractory Helicobacter pylori. The resistance rate was 34.1% for amoxicillin, 92.7% for clarithromycin, 65.9% for metronidazole, 85.4% for levofloxacin, and 29.3% for rifabutin. Dual resistance to both clarithromycin and levofloxacin was found in 73.2%. The antimicrobial resistance rate of refractory H. pylori was extremely high, which had become a major consideration in therapeutic challenge.

Keywords: Antimicrobial susceptibility; Refractory H. pylori; Resistance rate.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Multiple, Bacterial*
Female
Helicobacter Infections / drug therapy
Helicobacter Infections / epidemiology
Helicobacter Infections / microbiology*
Helicobacter pylori / drug effects*
Helicobacter pylori / isolation & purification
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Taiwan

Substances

Anti-Bacterial Agents