Exposure to phthalates and correlations with phthalates in dust and air in South China homes

Abstract

We spend more than half of our daily time in indoor environments, and the contributions of phthalates present in it to total exposure are important. Here, we determined phthalate concentrations in paired indoor settled dust/air and their metabolites in human urine from 100 general families in south China to explore such kind of effect. The total concentrations of phthalates/metabolites were 48.7-2850 μg/g, 279-5080 ng/m³ and 10.7-2840 ng/mL in the indoor dust, air and urine samples, respectively. Among all targets, di-n-butyl phthalate, di-isobutyl phthalate and di-(2-ethylhexyl) phthalate and their metabolites were the predominant compounds. The daily intakes (DIs) of phthalates via dust or air decreased with age, except for infant, and the values of dust ingestion, air inhalation and air dermal uptake were 2720 ± 2460, 1300 ± 973 and 3590 ± 2890 ng/kg/day for toddlers and 236 ± 194, 360 ± 179 and 1120 ± 586 ng/kg/day for adults, respectively. The ratios of DIs from air to dust were greater than 1.0 for people in all age groups, and the ratio was the highest for adults. Furthermore, the contributions of phthalates from indoor dust and air to total DIs from all sources (estimated from urinary phthalate metabolites) were 0.60%-5.23% and 2.65%-12.2% for different ages, respectively. Our results indicated that indoor air was a quite important source for human exposure to phthalates in indoor environment in south China.

Keywords: Air dermal uptake; Air inhalation; Exposure source analysis; Indoor environment; Phthalate exposure.