Unusual mechanical failures of intrathecal baclofen pump systems: symptoms, signs, and trouble shooting

Childs Nerv Syst. 2021 Aug;37(8):2597-2604. doi: 10.1007/s00381-021-05154-3. Epub 2021 Apr 8.

Abstract

Introduction: Although intrathecal baclofen (ITB) therapy is an effective treatment for spasticity, it has several disadvantages and a risk of complications.

Methods: We present six pediatric patients who suffered from unusual mechanical failures of intrathecal baclofen pump systems.

Results: With these case-vignettes, we provide a systematic approach on how to interpret the symptoms of ITB complications and an advice which further diagnostic and therapeutic steps to follow. We underline the seriousness of baclofen overdose, underdosing or withdrawal.

Keywords: Baclofen overdose; Baclofen pump complication; Baclofen withdrawal; Bisphosphonate therapy; Cerebral palsy; Intrathecal baclofen therapy; Spasticity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Baclofen / therapeutic use
  • Cerebral Palsy* / drug therapy
  • Child
  • Humans
  • Infusion Pumps, Implantable
  • Injections, Spinal
  • Muscle Relaxants, Central* / therapeutic use
  • Muscle Spasticity / drug therapy

Substances

  • Muscle Relaxants, Central
  • Baclofen